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Home Alzheimers and Dementia Genetics and Dementia: Why Men Shouldn’t Ignore Alzheimer’s Risk

Genetics and Dementia: Why Men Shouldn’t Ignore Alzheimer’s Risk

June 28, 2025amanna

Why men shouldn’t ignore Alzheimer’s risk

A nuanced shift in our comprehension of Dementia is significantly affecting men. For many years, researchers have focused their studies on Alzheimer’s (a form of dementia), examining factors such as age, lifestyle, and overall brain health. Recent research now highlights the role of genetics.

The Genetic Clue Hiding in Plain Sight

Recent research published in Neurology has shed light on a common genetic variant, H63D, found within the HFE gene that plays a crucial role in regulating iron levels in the body. This gene often comes up in discussions about hemochromatosis screening, but its connection to Dementia has not received the attention it deserves. This situation persisted until quite recently.

In a noteworthy discovery from the comprehensive ASPREE trial, researchers found that men with two copies of the H63D variant had more than double the likelihood of developing Dementia over their lifetime. When it comes to women, the risk factors are equally significant.

It is not just about medicine that makes the difference. It is time to make some changes. – John Olynyk

According to Professor John Olynyk from the Curtin Medical School, “possessing a single copy of this gene variant does not alter the risk of dementia; however, having two copies does increase that risk in men.” The risk extends beyond merely considering blood iron levels. Inflammation and nerve stress might also be contributing factors. These avenues, currently under investigation, hold promise for future treatments.

This is precisely where the opportunity arises. While your genes are fixed, you can influence their impact on your future.

The APOE-ε4 Puzzle: A Risk Factor with Reach

Here’s another genetic warning sign that stands out. The APOE-ε4 version! It is the most accurate genetic predictor of Alzheimer’s disease. This variant makes people of both sexes more likely to get sick, but symptoms appear later.

Here’s another genetic warning sign that catches the eye. The APOE-ε4 variant! This is the most precise genetic indicator of Alzheimer’s disease. This variant increases the likelihood of illness in individuals of all genders, although symptoms tend to manifest later on.

Recent research indicates that APOE-ε4 alters brain function early in life, affecting children as well. The adjustments may seem minor, yet they accumulate over time. Their effects vary from altering spatial memory to subtly modifying the signaling of neurons in the hippocampus. The molecular echoes can lead to confusion and memory loss commonly linked to Alzheimer’s, developing over many years.

Knowledge is powerful. Having APOE-ε4 does not mean your future is set in stone; there are steps you can take to improve it. Awareness paves the way for prevention and intervention.

Why Gender Matters in Dementia

Women are generally at a greater risk of developing Dementia than men; however, specific gene variants have a more pronounced impact on men. However, longevity contributes to the disparity in women, and genetics, particularly in men, has emerged as a critical area of investigation. The discovery of male-specific risks, such as the H63D variant, has transformed the narrative of Dementia, with men now actively participating in its development.

Historically, men have often been reluctant to seek assistance, delayed making plans, and resisted altering their lifestyles when confronted with cognitive challenges. That must change for their betterment.

Assisting Hands Gulf Coast offers comprehensive Alzheimer’s and dementia care for men and women. We assist seniors facing all kinds of Dementia with our Alzheimer’s and Dementia care services in Tampa, FL. Our caregivers are prepared to provide adequate home care for individuals dealing with:

  • Alzheimer’s
  • Dementia
  • Memory problems
  • Memory impairment from stroke, and
  • Other neurological disorders

We are prepared to deal with the unique challenges that these conditions bring.

Don’t Wait for Symptoms: Act Now:

For men, particularly those with a family history of Dementia or known genetic risk factors, the message is clear: act before symptoms manifest. Cognitive decline can creep up on you before you even realize it. Usually, it becomes more apparent in the later stages of life.

So what can you do?

Transform Your Lifestyle:

How you care for your body is the initial step towards achieving optimal brain health.

Stay active every day:

Everyone needs at least 30 minutes of aerobic exercise every day. Activities include taking brisk walks, swimming, or biking for enjoyable exercise.

Maintain Healthy Diet:

To keep your brain healthy, it’s important to maintain a healthy diet. Consider incorporating a Mediterranean-style approach that includes plenty of leafy greens, berries, nuts, and healthy fats.

Sleep well:

Sound sleep is essential for your brain, so do not compromise.

Maintain Weight:

Being overweight increases your risk of developing Dementia. High blood pressure and uncontrolled diabetes can be overwhelming for your overall health.

Stop Smoking & Drinking:

It’s time to stop smoking and drinking, as they are detrimental to brain health.

Train Your Brain:

  • Exercising your brain is akin to giving your muscles a good workout.
  • Engage in memory games, puzzles, or learn a new language.
  • Maintain your social life. Engaging in conversation, participating in community activities, and building friendships can significantly enhance your brain health.
  • Please address hearing loss, manage chronic illnesses, and identify which medications may impact your cognitive function.

Plan Your Steps

Dementia impacts more than just memory; it alters every aspect of life. That is why getting care planning right is crucial.

  • Advance directives empower you to advocate for your future.
  • Planning your finances allows you to maximize your savings to meet your needs effectively.
  • Legal protections are crucial in maintaining your independence and ensuring your wishes are honored.

Assisting Hands Gulf Coast offers personalized care plans to manage symptoms and enhance quality of life for individuals with Alzheimer’s and Dementia.

Ensuring Safety and Routine for Individuals with Memory Loss and Cognitive Impairment:

People with Alzheimer’s and Dementia experience memory loss which creates confusion and loss in mobility that would negatively affect how they take care of themselves in performing activities of daily living. As the condition progresses, wandering becomes a concern for family members. The decline in cognitive function leads to disorientation and confusion about location. Plus, mood swings become more frequent as daylight begins to fade like sundowning; restlessness and agitation cause discomfort and anxiety. No wonder, life becomes extremely challenging for both patients and their family members. That’s where Assisting Hands Gulf Coast professional and trained caregivers could help.

Maintaining consistencies, routines, and familiarity is crucial for individuals with experiencing memory loss. These elements provide a sense of order, reduce anxiety, and can help them with daily activities.

At Assisting Hands Home Care Gulf Coast, we come in to establish a supportive environment so they could stay at home safely and assist their family caregivers from experiencing burnout.

Here’s how we do our part:

We provide professional and compassionate caregivers who can help with:

Meal preparation:

Maintaining nutritious diet is crucial for Alzheimer’s patients. Our caregivers prepare special meals that help manage symptoms, improve overall health, and slow down the progression of the disease.

ADLs:

As conditions worsen, self-care becomes challenging. We provide assistance with basic activities, such as bathing, dressing, toileting, and feeding, honoring personal boundaries and ensuring their private moments are safe and meaningful.

Light Housekeeping:

We provide assistance with lighting housekeeping tasks, like cleaning, laundry, and dishwashing. A clean environment promotes comfort and peace at all times.

Companionship:

We provide emotional support and engage clients in activities to reduce feelings of loneliness and isolation.

Transportation:

Our professional and trained caregivers provide assistance with transportation to medical appointments, grocery shopping, and other activities.

Medication Reminders:

Our caregivers ensure timely medication reminders for medication schedules to promote adherence.

The Last Thing to Remember

With age, the condition may progress, making life challenging for family caretakers. Physical tasks like bathing, dressing, and toileting may require total assistance. That’s where Assisting Hands Gulf Coast could help. Our 24-hour home care services means there’s someone to notice and monitor your loved ones, fostering a sense of safety, support, and independence at home.

Tags: alzheimer’s and dementia care, gulf coast memory care
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